بررسی تداخل های دارویی دسته داروهای قلبی - عروقی در نسخ بیمه داروخانه های شهر ساری در سال 78- 79

Background and purpose: Drug interactions occur when two or more drugs are administered at a time. This will Çause a varying theraputic effect of a drug poisoning by other drugs of factors. Ïn this research, the prevalence of different degrees of interactions by Çardio-vascular drugs prescribed in insured prescriptions during the fist six months of the year 2000 in sari drug stores were evaluated. Materials and methods: This descriptive study was conducted on 11280 regular, randomly sampled insured prescriptions issued by general physicians and specialists during the fist six months of the year 2000 in eight drug stores of sari township. Drug interactions were studied on the basis of the rating by Drug Ïnteraction Facts book. Results: 9.31% of the prescriptions had at least one cardiovascular drug (57.43% in females and 42.57% males.) 40.2% of the cardiovascular drugs were prescribed by cardiologists, 18.4% by other specialists and 41.4% by general physicians. Drug interaction was observed in 50% of the prescriptions and type of interaction from first degree to fifth degree was 10.82, 14.53, 7.85, 46.01 and 20.78 percent respectively. High prevalence of prescribed drugs and also drug interactions belonged to beta blocker group of drugs. The mean of number of drugs prescribed was 3.68 ± 1.21 and mean of number of Çardio vascular drugs prescribed was 1.87 ± 1.12. Ân increase in the number of prescribed drugs in a prescription is directely proportional to the rate of drug interaction. Çonclusion: High prevalence of cardio vascular drug interactions in these prescriptions emphasizes a proper attention to be paied to practical pharmacology by practicioners and pharmacologists.